By Stephen T. Holgate MD DSc FRCP FRCPE MRC, Martin K. Church MPHARM PhD DSc, Fernando D Martinez MD, Lawrence M. Lichtenstein MD PhD
This accomplished, clinically orientated full-color source provides you with a wealth of particular info at the analysis, remedy, and administration of allergic diseases—from bronchial asthma to urticaria. completely up-to-date to mirror cutting-edge wisdom, this third version positive aspects all the most up-to-date advancements in hypersensitive reaction and immunology. Plus, a constant, logical association places important info at your fingertips.
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Additional resources for Allergy
The parenchymal nature of the disorder was not clearly distinguished from asthma until 1932, when Campbell published a report describing three English farm workers; the term farmers’ lung was introduced later in 1944. Nonetheless, EAA was recognized in Iceland in the nineteenth century, and probably contributed to the occupational ailments of grain workers graphically described by Ramazzini in the eighteenth century. It was not until 1961, when Pepys and colleagues demonstrated the presence of precipitins to antigens of moldy hay in patients suffering from farmers’ lung, that the idea of an allergic etiology gained general acceptance.
Very fine collagen and elastic fibers also accompany the capillaries to provide mechanical support and elastic recoil. In extrinsic allergic alveolitis (EAA) this interstitium is infiltrated by inflammatory cells, predominantly lymphocytes and macrophages, which may restrict gas exchange. There is hyperplasia of the type 2 pneumocytes (Pn 2) and a marked increase in the number of alveolar lymphocytes. A higher power view of an alveolar space in EAA demonstrates numerous small mainly lymphocytic mononuclear cells, and large foamy macrophages with abundant, light pink cytoplasm (stained with hematoxylin and eosin), and central, vesicular nuclei.
This could allow international standardization and quality control, and facilitate comparison of results between centers. In addition to improved diagnosis, this may improve the understanding of the immunopathogenic mechanisms of EAA. ANATOMY AND PHYSIOLOGY OF THE ALVEOLI The alveoli represent the terminal respiratory units of the lung. The term alveolar tissue applies to that anatomic part of the lung which contains the alveoli and is capable of gas exchange – it includes both the alveolar ducts and sacs (Fig.
Allergy by Stephen T. Holgate MD DSc FRCP FRCPE MRC, Martin K. Church MPHARM PhD DSc, Fernando D Martinez MD, Lawrence M. Lichtenstein MD PhD