By Philip W. Harvey, David J. Everett, Christopher J. Springall
Despite being considered as the commonest toxicological goal within the endocrine approach, the adrenal gland has frequently been overlooked in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations to be had to check adrenal endocrine disruption.
Examining present concepts and the newest developments, Adrenal Toxicology stories the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers info at the diversity of substances and chemical compounds that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro overview. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.
Adrenal Toxicology :
- reflects the main advancements remodeled the previous decade
- focuses at the most modern study suggestions, together with their makes use of and limitations
- provides an built-in method for adrenal toxicology evaluation
- identifies wisdom and knowledge gaps, offering impetus for regulatory consideration
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Extra resources for Adrenal Toxicology
Individual compounds may also induce adrenocortical toxicity by more than one mechanism. , 1998) in H295R cells. Mixtures or combined exposures of different chemicals may also interact to affect adrenocortical function. Recently Li and Lin (2007) reported that potassium provokes both aldosterone and cortisol biosynthesis in H295R cells, and that pretreatment with polychlorinated biphenyl126 synergistically increased the effects of potassium. The additive or synergistic responses to combined exposures are a particularly important consideration in toxicology, and real-life exposures of both humans and animals are to multiple chemical compounds.
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J Pediatr 2004; 145:178–183. Gell JS, Oh J, Rainey WE, et al. Effect of estradiol on DHEAS production in the human adrenocortical cell line, H295R. J Soc Gynecol Invest 1998; 5:144–148. Goldberg A. Etomidate. Lancet 1983; 1983 ii, 60. Gracia T, Hilscherova K, Jones PD, et al. The H295R system for evaluation of endocrinedisrupting effects. Ecotoxicol Environ Saf 2006; 63:293–305. Gracia T, Hilscherova K, Jones PD, et al. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds.
Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall