Download e-book for kindle: Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the commonest toxicological goal within the endocrine approach, the adrenal gland has frequently been overlooked in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations to be had to check adrenal endocrine disruption.

Examining present concepts and the newest developments, Adrenal Toxicology stories the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers info at the diversity of substances and chemical compounds that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro overview. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the main advancements remodeled the previous decade
  • focuses at the most modern study suggestions, together with their makes use of and limitations
  • provides an built-in method for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, offering impetus for regulatory consideration

Show description

Read or Download Adrenal Toxicology PDF

Similar endocrinology books

New PDF release: Islet Transplantation and Beta Cell Replacement Therapy

Beta cellphone alternative via transplantation is still the single remedy alternative for style 1 diabetes permitting recovery of near-physiological glucose degrees with no major hypoglycemia. Outlining the newest advances and study breakthroughs, this useful consultant and reference paintings explores the impression of islet telephone transplantation and brings jointly major multidisciplinary proponents serious to destiny good fortune within the box.

Download PDF by Thomas Seyfried: Cancer as a Metabolic Disease: On the Origin, Management and

The publication addresses controversies regarding the origins of melanoma and gives options to melanoma administration and prevention. It expands upon Otto Warburg's recognized idea that each one melanoma is a ailment of strength metabolism.  although, Warburg didn't hyperlink his concept to the "hallmarks of melanoma" and therefore his thought was once discredited.

Practical Algorithms by George Richard Yool PDF

An set of rules is an answer to a category of difficulties usually contained in programming unit known as a module and accessed via a number of objected orientated courses. a category on algorithms is a category on challenge fixing with the expectancy of marketable effects. This calls for a textbook that really offers challenge fixing instruments.

Extra resources for Adrenal Toxicology

Sample text

Individual compounds may also induce adrenocortical toxicity by more than one mechanism. , 1998) in H295R cells. Mixtures or combined exposures of different chemicals may also interact to affect adrenocortical function. Recently Li and Lin (2007) reported that potassium provokes both aldosterone and cortisol biosynthesis in H295R cells, and that pretreatment with polychlorinated biphenyl126 synergistically increased the effects of potassium. The additive or synergistic responses to combined exposures are a particularly important consideration in toxicology, and real-life exposures of both humans and animals are to multiple chemical compounds.

Lancet 1983; 1983 ii, 60. Gracia T, Hilscherova K, Jones PD, et al. The H295R system for evaluation of endocrinedisrupting effects. Ecotoxicol Environ Saf 2006; 63:293–305. Gracia T, Hilscherova K, Jones PD, et al. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicol Appl Pharmacol 2007; 225:142–153. Gumbleton M, Nicholls PJ. Molecular and systems pharmacology of glucocorticosteroids. In: Harvey PW, ed.

J Pediatr 2004; 145:178–183. Gell JS, Oh J, Rainey WE, et al. Effect of estradiol on DHEAS production in the human adrenocortical cell line, H295R. J Soc Gynecol Invest 1998; 5:144–148. Goldberg A. Etomidate. Lancet 1983; 1983 ii, 60. Gracia T, Hilscherova K, Jones PD, et al. The H295R system for evaluation of endocrinedisrupting effects. Ecotoxicol Environ Saf 2006; 63:293–305. Gracia T, Hilscherova K, Jones PD, et al. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds.

Download PDF sample

Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall


by Mark
4.2

Rated 4.47 of 5 – based on 19 votes