Download PDF by H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip: 38th International Symposium on Growth Hormone and Growth

By H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler

ISBN-10: 331801446X

ISBN-13: 9783318014464

ISBN-10: 3805582552

ISBN-13: 9783805582551

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Read Online or Download 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) PDF

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Additional info for 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research)

Example text

It was thought that the main mechanism was an increase in bone mineral density. However, it has become apparent that the increase in bone mineral density associated with anticatabolic drugs such as risedronate, alendronate and raloxifene accounts for only 10% of the fracture benefit. It is more likely that the most important effect of these treatments is to decrease the rate of bone turnover to levels found in healthy premenopausal women. Indeed, the change in bone turnover markers accounts for up to 70% of the fracture risk reduction with risedronate [7].

However, this large randomized, controlled trial also showed that HRT was associated with increased risks of cardiovascular events and stroke, as well as the known side effects of increased risks of breast cancer and venous thromboembolic disease. Consequently, HRT is not commonly recommended for the prevention of fracture risk. Raloxifene Raloxifene binds to the oestrogen receptor, like the oestrogen in HRT, but in some tissues it acts as an oestrogen agonist, and in others it acts as an oestrogen antagonist.

The mechanism whereby GH secretion is switched off remains unknown. It is possible that during puberty a threshold level of ‘free IGF-I’ is reached, which down-regulates the system, although GH, IGF-I and insulin probably continue to play an important role in later gains of lean body mass in males and in bone mass in both sexes after peak height velocity. In childhood and adolescence, the relationship between GH and IGF-I is linear, but there is evidence for a continuation of the nutritional regulation of growth [34].

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38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) by H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler


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